© Benaki Phytopathological Institute
        
        
          Kasiotis & Machera
        
        
          34
        
        
          stems from parasites, pesticides and the
        
        
          poor flower diversity seems to be related to
        
        
          bee declines (Goulson
        
        
          et al.,
        
        
          2015). Indica-
        
        
          tive symptoms provoked by sublethal doses
        
        
          of IMI in honeybees are the decrease in the
        
        
          hypopharyngeal gland size, and respirato-
        
        
          ry rhythm (Hatjina
        
        
          et al
        
        
          ., 2013). Nonetheless,
        
        
          impairment of memory and brain metabo-
        
        
          lism has also been reported (Decourtye
        
        
          et
        
        
          al
        
        
          ., 2003). In this context, NNDs’ presence in
        
        
          human organisms is overshadowed by their
        
        
          impact especially on bees, and the relative-
        
        
          ly moderate to low toxicity that they exhib-
        
        
          it with respect to other more hazardous for
        
        
          human health pesticides, such as organo-
        
        
          phosphates, carbamates and pyrethroids
        
        
          (Dawson
        
        
          et al
        
        
          ., 2010).
        
        
          Humans are exposed to numerous pol-
        
        
          lutants
        
        
          via
        
        
          their diet (Domingo
        
        
          et al
        
        
          ., 2008; Lu
        
        
          et al
        
        
          ., 2008; Marti-Cid
        
        
          et al
        
        
          ., 2008b, a, c), the
        
        
          drinking water (Benotti
        
        
          et al
        
        
          ., 2009), and the
        
        
          pollution of several environmental compart-
        
        
          
            Figure 1.
          
        
        
          Chemical structures of Neonicotinoids